Following is my analysis of the 42 year old female patient multiple problems which she had since birth (Overview of G6PD deficiency: (Edema was extremely fluctuating within days and trigger points as mentioned by the patient were Emotional stress, Eating wrong food, Exercise in excess, Smoke. It relieved spontaneously. Associated with SOB and dark urine. These features are suggestive of G6PD deficiency which causes damage to the organs like kidney by free radicals because of lack of NADPH. Also kidney needs a lot of energy for ions active transport and water balance in the body. The Edema have occurred because of excessive loss of ions. Also the Hemolysis caused because of G6PD deficiency is responsible for fatigue and SOB because of reduced red blood cell count. The same must have been the reason for dark coloured urine also as complained by the patient.) POSSIBLE TRIGGERS IN THIS PATIENT ARE: Infections:recurrent UTI and pneumonia infections Severe reaction